Supplements for Cognitive Function Support: COSMOS-Mind Clinical Study

Q: How Did Centrum Silver Participate?

The multivitamin selected for the study was Centrum Silver —a multivitamin specially formulated for older adults. To advance the science of nutrition and participate in an Investigator Sponsored Study (ISS), Haleon provided Centrum Silver Adult Tablets Multivitamin, placebos and packaging for the trial.

Cognitive health, defined as the ability to think, learn and remember, is an essential component of our overall well-being as we age.¹ Finding a way to support cognitive function in older adults is an important public health issue, as roughly two out of every three Americans experience some level of cognitive impairment around the age of 70.² We know that multivitamins are a practical and effective way to complement a healthy diet and support general health. The recent COSMOS-Mind clinical study also found that multivitamins can play a role in supporting healthy aging, especially cognitive functioning.

Grandmother and granddaughter playing checkers

What Is the COSMOS-Mind Study?

The COSMOS-Mind trial was an ancillary study funded by NIH and conducted by investigators at Wake Forest University. The three-year trial investigated the effects of multivitamin and cocoa flavonoid consumption on cognitive functioning in 2,262 women and men, 65 and older. The Wake Forest COSMOS-Mind team tested each participant’s cognitive function via annual cognitive assessments.³

How Did Centrum Silver Participate?

The multivitamin selected for the study was Centrum Silver—a multivitamin specially formulated for older adults. To advance the science of nutrition and participate in an Investigator Sponsored Study (ISS), Haleon provided Centrum Silver Adult Tablets Multivitamin, placebos and packaging for the trial.

COSMOS-Mind Clinical Study Results

The trial found that taking Centrum Silver multivitamins daily could help support cognitive function, memory and executive function in older adults. The participants who took Centrum Silver had significant improvements in the following areas:

Overall cognitive function.
Episodic memory—which is a type of memory, or information about recent or past events and experiences.⁴
Executive function—the cognitive skills we need to carry out everyday activities.⁵

Overall, this exciting study shows promise for the role Centrum Silver multivitamins can have in supporting cognitive health in older adults.

The Importance of Cognitive Health

As we age, we start to develop concerns around supporting cognitive abilities and memory. In 2019, around a quarter of all Americans over the age of 50 regularly took supplements to support their brain health.⁶ Cognitive health is one part of our overall brain health and a major factor in determining the quality of life for older adults and their ability to maintain independence.^1,7 The positive results from the COSMOS-Mind study show that an intervention as simple as taking Centrum Silver daily could help support cognitive function, memory and executive function.

Centrum Silver Multivitamins

In addition to Centrum Silver Adults, Centrum also offers Centrum Silver Men and Centrum Silver Women multivitamins. These multivitamins also come in smaller tablets that are easier to swallow. As you age, your nutritional requirements begin to shift naturally. Centrum Silver Men is a multivitamin crafted to help meet the essential vitamin and mineral needs of men over 50, including Zinc and B-vitamins to help support normal brain function and vitamin D and B6 to support muscle function.*^ Centrum Silver Women is a supplement made with essential vitamins and minerals like vitamin D and calcium to help maintain strong bones and zinc and B-vitamins to help support normal brain function*^ in women over 50. Refer to the Alzheimer & Dementia journal for more information on this clinical study.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

^Zinc and B-vitamins help support normal brain function. Vitamin D and B6 help support muscle function. A combination of vitamin D and calcium helps maintain strong bones.

Show References
Cognitive Health and Older Adults | National Institute on Aging. https://www.nia.nih.gov/health/cognitive-health-and-older-adults. Accessed 8/10/22.

Cognitive impairment in the U.S.: Lifetime risk, age at onset, and years impaired. PMC (nih.gov). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153285/. Accessed 8/10/22.

Cocoa Supplement and Multivitamin Outcomes Study for the Mind. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/study/NCT03035201. Accessed 8/10/22.

Memory | Memory and Aging Center. https://memory.ucsf.edu/symptoms/memory. Accessed 8/10/22.

Executive Functions | Memory and Aging Center. https://memory.ucsf.edu/symptoms/executive-functions. Accessed 8/10/22.

The Real Deal on Brain Health Supplements. AARP.org. https://www.aarp.org/content/dam/aarp/health/brain_health/2019/06/gcbh-supplements-report-english.doi.10.26419-2Fpia.00094.001.pdf. Accessed 8/10/22.

Perceptions of Cognitive Health Factsheet. CDC. https://www.cdc.gov/aging/pdf/perceptions_of_cog_hlth_factsheet.pdf. Accessed 8/10/22.

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