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Multivitamin Supplementation for Memory Support: COSMOS-Web Clinical Study

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Just like all parts of our bodies, changes in our brain occur as we age. Nutrition, among other factors like exercise and adequate sleep, is one piece to support brain health with aging. With age, getting adequate nutrition to keep us at our best can be difficult.1 Multivitamins are a practical and effective way to complement a healthy diet and support overall health. With its publication in May of 2023, COSMOS-Web clinical study added to the mounting evidence that Centrum Silver multivitamins support cognitive functions, specifically memory, in older adults.*

What is the COSMOS-Web Clinical Study?

The COSMOS-Web trial was an NIH funded, independent study conducted off the parent COSMOS trial by investigators at Brigham and Women’s Hospital-Harvard University and Columbia University. This was a three-year, double-blind, randomized controlled trial examining the effects of a multivitamin on memory in 3,562 women and men aged 60 and older. Memory is our ability to recall information2 and it was assessed at baseline and annually through Web-based cognitive assessment tools during the trial.3

How Did Centrum Silver Participate?

Centrum Silver, a multivitamin formulated for older adults, was selected for the study. With our ongoing commitment to advancing nutritional science as the most clinically studied multivitamin brand, Haleon provided Centrum Silver Adult Tablets, placebos, and packaging. Haleon had no role in the design or conduct of the study, any interpretation of the data, or authorship in the study publication.

COSMOS-Web Clinical Study Results

Researchers found that taking Centrum Silver multivitamins helps support memory in older adults. The participants who took Centrum Silver had statistically significant improvements in memory recall tests compared to placebo in one year, with persistent effects for 3 years.

The results of the COSMOS-Web study provide further support for the cognitive benefits found in the COSMOS-Mind trial which found that taking Centrum Silver daily had significant improvements on overall cognition, episodic memory, and executive function tests in older adults.4 The results of these two studies show the role of Centrum Silver multivitamins on supporting cognitive function, memory, and overall healthy aging in older adults.

*This statement has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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Source Citations:

  1. Subpopulations at Risk for Micronutrient Inadequacy or Deficiency. Linus Pauling Institute.
  2. Memory | Harvard Health.
  3. Yeung LK, Alschuler DM, Wall M, et al. Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial. Am J Clin Nutr. 2023;118(1):273-282. doi:10.1016/j.ajcnut.2023.05.011.
  4. Baker LD, Manson JE, Rapp SR, et al. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimers Dement. 2023;19(4):1308-1319. doi:10.1002/alz.12767.
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